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Fluticasone furoate, sold under the brand name Flonase Sensimist among others, is a corticosteroid for the treatment of non-allergic and allergic rhinitis administered by a nasal spray. [9] It is also available as an inhaled corticosteroid to help prevent and control symptoms of asthma .
Fluticasone works as a potent anti-inflammatory agent, inhibiting multiple cell types such as mast cells, eosinophils, basophils, lymphocytes, macrophages, and neutrophils all of which contribute to inflammation, a large component in the pathogenesis of asthma.
Fluticasone furoate (Arnuity Ellipta, Relvar Ellipta) Fluticasone furoate/vilanterol (Breo Ellipta, Relvar Ellipta) Fluticasone furoate/umeclidinium bromide/vilanterol (Trelegy Ellipta) Umeclidinium bromide (Incruse Ellipta) Umeclidinium bromide/vilanterol (Anoro Ellipta)
In 2022, the combination azelastine/fluticasone was the 299th most commonly prescribed medication in the United States, with more than 300,000 prescriptions. [8] [9]
Fluticasone propionate was patented in 1980, and approved for medical use in 1990. [14] It is available as a generic medication. [10] In 2022, fluticasone was the 25th most commonly prescribed medication in the United States, with more than 22 million prescriptions. [15] [16]
Silver also steps up during inflationary periods but with more dramatic swings. He notes that silver surged from $18 per ounce in early 2020 to over $28 per ounce — a 55% increase.