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MDMA/citalopram is a combination of the entactogen and monoamine releasing agent 3,4-methylenedioxymethamphetamine (MDMA; also known as midomafetamine or "ecstasy") and the selective serotonin reuptake inhibitor (SSRI) citalopram which is under development for the treatment of post-traumatic stress disorder (PTSD).
Ricaurte is best known for investigating how methamphetamine damages dopamine neurons, and whether MDMA (ecstasy) damages serotonin neurons. [1] The long-term goal of this neurotoxicology research is to help find ways to prevent or retard the progression of Parkinson's disease and related neurodegenerative disorders.
"Recreational Use of Ecstasy Causes New Brain Damage: Trend to sequential doses of popular drug can have long-term lasting effects". The JHU Gazette (Johns Hopkins University Gazette). 32 (5). Baltimore, Maryland, United States of America: Johns Hopkins University. Archived from the original on 21 April 2017
She spent three months on life support and two weeks in a coma after taking one capsule of MDMA. Family posts shocking video of teen's brain damage after trying ecstasy drug Skip to main content
Administration of MDMA to mice causes DNA damage in their brain, [83] especially when the mice are sleep deprived. [84] Even at the very low doses that are comparable to those self-administered by humans, MDMA causes oxidative stress and both single and double-strand breaks in the DNA of the hippocampus region of the mouse brain. [85]
Psychoactive drugs operate by temporarily affecting a person's neurochemistry, which in turn causes changes in a person's mood, cognition, perception and behavior. There are many ways in which psychoactive drugs can affect the brain. Each drug has a specific action on one or more neurotransmitter or neuroreceptor in the brain.
A common theory follows that a metabolite of MDA and MDMA in the periphery must be responsible, and several have been cited as responsible. Although α-methyldopamine is widely cited as the source of this neurotoxicity in a number of lay sources, McCann, et al. (1991), demonstrated that the major metabolites α-methyldopamine and 3- O -methyl ...
The whole experience is long-lasting and can be too intense as all of these molecules synergize and potentiate each other. 2C-B: MDMA: Nexus flip [9] [10] Nexus flipping [9] [10] The MDMA is often taken first and the 2C-B after the end of the MDMA peak (h+2/h+2.½). [11] The 2C-B is supposed to help the empathogenic effect of the MDMA last ...