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Four motor symptoms are considered cardinal signs in PD: slowness of movement (bradykinesia), tremor, rigidity, and postural instability. [1] Typical for PD is an initial asymmetric distribution of these symptoms, where in the course of the disease, a gradual progression to bilateral symptoms develops, although some asymmetry usually persists.
Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia (slowed movements), rigidity, and postural instability. [1] [2] Both hypokinetic (bradykinesia and akinesia) as well as hyperkinetic (cogwheel rigidity and tremors at rest) features are displayed by Parkinsonism. [3]
Myerson's sign or glabellar tap sign is a clinical physical examination finding in which a patient is unable to resist blinking when tapped repetitively on the glabella, the area above the nose and between the eyebrows.
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Agricultural areas are associated with higher Parkinson's prevalence, possibly due to exposure to pesticides and industrial waste. As of 2024, Parkinson's is the second most common neurodegenerative disease and the fastest-growing in total number of cases. [231] [232] As of 2023, global prevalence was estimated to be 1.51 per 1000. [233]
Parkinsonian gait (or festinating gait, from Latin festinare [to hurry]) is the type of gait exhibited by patients with Parkinson's disease (PD). [2] It is often described by people with Parkinson's as feeling like being stuck in place, when initiating a step or turning, and can increase the risk of falling. [3]