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The oxygen enhancement ratio (OER) or oxygen enhancement effect in radiobiology refers to the enhancement of therapeutic or detrimental effect of ionizing radiation due to the presence of oxygen. This so-called oxygen effect [ 1 ] is most notable when cells are exposed to an ionizing radiation dose .
The best known explanation of the oxygen effect is the oxygen fixation hypothesis developed by Alexander in 1962, [9] which posited that radiation-induced non-restorable or "fixed" nuclear DNA lesions are lethal to cells in the presence of diatomic oxygen. [10] [11] Recent hypotheses include one based on oxygen-enhanced damage from first ...
Oxygen enhancement ratio, effect magnitude of ionizing radiation due to the presence of oxygen Oxygen Evolution Reaction , the formation of oxygen by electrochemical reduction of water Owner’s Equivalent Rent, an economic metric for housing prices often used in the calculation of market baskets
V̇O 2 max (also maximal oxygen consumption, maximal oxygen uptake or maximal aerobic capacity) is the maximum rate of oxygen consumption attainable during physical exertion. [1] [2] The name is derived from three abbreviations: "V̇" for volume (the dot over the V indicates "per unit of time" in Newton's notation), "O 2" for oxygen, and "max" for maximum and usually normalized per kilogram of ...
Multiple studies have investigated this possibility, one being Jin. et al., 2020, where it was observed that circulating blood cells experienced a significantly lower impact during FLASH-RT, resulting in the killing of only 5-10% of cells, in contrast, CONV-RT exhibited a much more substantial effect, leading to the death of 90-100% of cells. [14]
Tumor stroma and extracellular matrix in hypoxia. Tumor hypoxia is the situation where tumor cells have been deprived of oxygen.As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues.
[59] [60] [61] Articles based in murburn concept were given cover-page credits in four annual volumes (2017, 2018, 2019 and 2020) of Biomedical Reviews (the official journal of Bulgarian Society for Cell Biology) and the 167th (December 2021) volume of Progress in Biophysics and Molecular Biology (Elsevier). The advocates of murburn concept ...
A breathing gas is a mixture of gaseous chemical elements and compounds used for respiration. Air is the most common and only natural breathing gas. Other mixtures of gases, or pure oxygen, are also used in breathing equipment and enclosed habitats such as scuba equipment, surface supplied diving equipment, recompression chambers, high-altitude mountaineering, high-flying aircraft, submarines ...