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Lubiprostone, sold under the brand name Amitiza among others, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. The drug is owned by Mallinckrodt and is marketed by Takeda Pharmaceutical Company.
Prucalopride is contraindicated where there is hypersensitivity to the active substance or to any of the excipients, renal impairment requiring dialysis, intestinal perforation or obstruction due to structural or functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract, such as Crohn's disease, and ulcerative colitis and toxic megacolon ...
Lubiprostone, a derivative of prostaglandin E1, is also used as a medication. [2] [3] Prostaglandin E 1 is a vasodilator. It has various effects in the body that include opening blood vessels, relaxing smooth muscle, inhibiting clotting, and causing uterine contractions. [2] [4]
Crisdesalazine (INN Tooltip International Nonproprietary Name; developmental code name AAD-2004) is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor and free radical scavenger which is under development for the treatment of Alzheimer's disease, amyotrophic lateral sclerosis (ALS), depressive disorders, Parkinson's disease, and spinal muscular atrophy.
ATC code A06 Drugs for constipation is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
There should be only 5 carbons at the side chain of 1,1-difluoropentyl. And the formula of lubiprostone only 20 carbons, but the structure shows 21 carbons. —Preceding unsigned comment added by 211.78.179.120 15:24, 9 March 2008 (UTC) The current structure is correct. ChemNerd 20:34, 13 March 2012 (UTC)
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by a group of symptoms that commonly include abdominal pain, abdominal bloating and changes in the consistency of bowel movements. [1]
Liquid paraffin is primarily used as a pediatric laxative in medicine and is a popular treatment for constipation and encopresis. [1] Because of its ease of titration, the drug is convenient to synthesize.