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Knockout studies in Aplysia sea slugs indicated that decreasing CREB function blocks long-term changes in synaptic function, but not short-term ones. [3] Changes in synaptic function (i.e., synaptic plasticity) are required for learning and memory [4] As evidence of this, a line of mice with a targeted disruption of the α and δ isoforms of CREB showed intact short-term memory, but disrupted ...
Treatment with the cancer drug restored function in the hippocampus in an Alzheimer’s mouse model. It has long been understood that glucose metabolism in the brain is disrupted by aging and ...
Hippocampal sclerosis is the most common brain abnormality in those with temporal lobe epilepsy. [16] Hippocampal sclerosis may occur in children under 2 years of age with 1 instance seen as early as 6 months. [17] About 70% of those evaluated for temporal lobe epilepsy surgery have hippocampal sclerosis.
However, an excess of cortisol can impair the ability of the hippocampus to both encode and recall memories. [2] These stress hormones are also hindering the hippocampus from receiving enough energy by diverting glucose levels to surrounding muscles. [2] Stress affects many memory functions and cognitive functioning of the brain. [10]
MTL amnesic patients with localized damage to the hippocampus retain other perceptual abilities, such as the ability to intelligently function in society, to make conversation, to make one's bed, etc. Anterograde amnesics without combined retrograde disorders (localized damage to the MTL system) have memories prior to the traumatic event.
Long-term potentiation (LTP) is a persistent increase in synaptic strength following high-frequency stimulation of a chemical synapse.Studies of LTP are often carried out in slices of the hippocampus, an important organ for learning and memory.
This is due to the fact that dentate granule cells play a critical role in the function of the entorhinal-hippocampal circuitry in health and disease. Dentate granule cells are situated to regulate the flow of information into the hippocampus, a structure required for normal learning and memory. [24]
This sort of memory can last for a lifetime. Much evidence implicates the hippocampus in playing a crucial role: people with severe damage to the hippocampus sometimes show amnesia, that is, inability to form new long-lasting episodic memories. [116] Semantic memory is the ability to learn facts and relationships. This sort of memory is ...