Search results
Results From The WOW.Com Content Network
Phosphoinositide 3-kinase inhibitors (PI3K inhibitors) are a class of medical drugs that are mainly used to treat advanced cancers. They function by inhibiting one or more of the phosphoinositide 3-kinase (PI3K) enzymes, which are part of the PI3K/AKT/mTOR pathway. This signal pathway regulates cellular functions such as growth and survival. It ...
Class II catalyse the production of PI(3)P from PI and PI(3,4)P 2 from PI(4)P; however, little is known about their role in immune cells. PI(3,4)P 2 has, however, been shown to play a role in the invagination phase of clathrin-mediated endocytosis. [17] C2α and C2β are expressed through the body, but expression of C2γ is limited to hepatocytes.
AKT can have a number of downstream effects such as activating CREB, [2] inhibiting p27, [3] localizing FOXO in the cytoplasm, [3] activating PtdIns-3ps, [4] and activating mTOR [3] which can affect transcription of p70 or 4EBP1. [3] There are many known factors that enhance the PI3K/AKT pathway including EGF, [5] shh, [2] IGF-1, [2] insulin ...
Pricing is the process whereby a business sets and displays the price at which it will sell its products and services and may be part of the business's marketing plan.In setting prices, the business will take into account the price at which it could acquire the goods, the manufacturing cost, the marketplace, competition, market condition, brand, and quality of the product.
Using methylmagnesium bromide as the alkylation agent, salts of Fe(CH 3) 4] − have been isolated. [29] Illustrating the sensitivity of these reactions, methyl lithium LiCH 3 reacts with iron(III) chloride to give lithium tetrachloroferrate(II) Li 2 [FeCl 4]: [30] 2 FeCl 3 + LiCH 3 → FeCl 2 + Li[FeCl 4] + 0.5 CH 3 CH 3 Li[FeCl 4] + LiCH 3 ...