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Kallmann syndrome is a form of a group of conditions termed hypogonadotropic hypogonadism. [1] To distinguish it from other forms of hypogonadotropic hypogonadism, Kallmann syndrome has the additional symptom of a total lack of sense of smell (anosmia) or a reduced sense of smell.
CHH is divided into 2 subtypes depending on the condition of the olfactory system, anosmic HH (Kallman syndrome) and normosmic HH. [8] AHH is an acquired form of the disease often occurring after sexual maturation and is not related to genetic defects. [4] AHH can also be developed through drug and alcohol use and encephalic trauma. [8]
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The following diagnostic systems and rating scales are used in psychiatry and clinical psychology.This list is by no means exhaustive or complete. For instance, in the category of depression, there are over two dozen depression rating scales that have been developed in the past eighty years.
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[2] [3] Alternatively, the Montgomery-Åsberg Depression Rating Scale (MADRS) features ten items to be completed for the purpose of assessing the effects of drug therapy, [2] [4] Another scale is the Raskin Depression Rating Scale rating the severity of the patients' symptoms in three areas: verbal reports, behavior, and secondary symptoms of ...
In human it is located on the X chromosome at Xp22.3 and is affected in some male individuals with Kallmann syndrome. [2] This gene codes for a protein of the extracellular matrix named anosmin-1, which is involved in the migration of certain nerve cell precursors (neuroendocrine GnRH cells) during embryogenesis .
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