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ALK positive lung cancer is a primary malignant lung tumor whose cells contain a characteristic abnormal configuration of DNA wherein, most frequently, the echinoderm microtubule-associated protein-like 4 gene is fused to the anaplastic lymphoma kinase (ALK) gene.
Xalkori , produced by Pfizer, was approved by the FDA for treatment of late stage lung cancer on August 26, 2011. [76] Early results of an initial Phase I trial with 82 patients with ALK induced lung cancer showed an overall response rate of 57%, a disease control rate at 8 weeks of 87% and progression free survival at 6 months of 72%.
The drug treats a type of non-small cell lung cancer with a genetic mutation called ALK. Non-small cell lung cancers account for about 85% of lung cancer diagnoses, and ALK-positive cancers ...
Micrograph showing an ALK positive adenocarcinoma of the lung.The ALK immunostain allows individuals with ALK rearrangements to be identified.. ALK inhibitors are anti-cancer drugs that act on tumours with variations of anaplastic lymphoma kinase (ALK) such as an EML4-ALK translocation. [1]
The European Commission has approved Pfizer Inc's (NYSE: PFE) Lorviqua (lorlatinib) for a form of advanced non-small-cell lung cancer (NSCLC). Lorlatinib is available in the U.S. under the brand ...
Adenocarcinoma of the lung is the most common type of lung cancer, and like other forms of lung cancer, it is characterized by distinct cellular and molecular features. [1] It is classified as one of several non-small cell lung cancers (NSCLC), to distinguish it from small cell lung cancer which has a different behavior and prognosis.
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