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Pyuria is the condition of urine containing white blood cells or pus. Defined as the presence of 6-10 or more neutrophils per high power field of unspun, voided mid-stream urine, it can be a sign of a bacterial urinary tract infection. Pyuria may be present in people with sepsis, or in older people with pneumonia.
Urine may contain pus (a condition known as pyuria) as seen from a person with sepsis due to a urinary tract infection. Lower urinary tract infection is also referred to as a bladder infection. The most common symptoms are burning with urination and having to urinate frequently (or an urge to urinate) in the absence of vaginal discharge and ...
Bacteriuria is assumed if a single bacterial species is isolated in a concentration greater than 100,000 colony forming units per millilitre of urine in clean-catch midstream urine specimens. [16] In urine samples obtained from women, there is a risk for bacterial contamination from the vaginal flora.
In highly concentrated urine they may shrivel and develop a spiky shape, which is termed crenation, while in dilute urine they can swell and lose their hemoglobin, creating a faint outline known as a ghost cell. A small quantity of red blood cells in the urine is considered normal. [93] [97] An increased level of RBCs is termed hematuria.
Analysis of the urine may show signs of urinary tract infection. Specifically, the presence of nitrite and white blood cells on a urine test strip in patients with typical symptoms are sufficient for the diagnosis of pyelonephritis, and are an indication for empirical treatment. Blood tests such as a complete blood count may show neutrophilia.
Pus is an exudate, typically white-yellow, yellow, or yellow-brown, formed at the site of inflammation during infections, regardless of cause. [1] [2] An accumulation of pus in an enclosed tissue space is known as an abscess, whereas a visible collection of pus within or beneath the epidermis is known as a pustule, pimple or spot.
In urine cytology, collected urine is examined microscopically. One limitation, however, is the inability to definitively identify low-grade cancer cells and urine cytology is used mostly to identify high-grade tumors. [4] If the test detects atypical or cancerous cells, further tests may be recommended, such as cystoscopy and a CT scan.
Staphylococcus saprophyticus was not recognized as a cause of urinary tract infections until the early 1970s, more than 10 years after its original demonstration in urine specimens. Prior to this, the presence of coagulase-negative staphylococci (CoNS) in urine specimens was dismissed as contamination. [citation needed]