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As an ingredient in skin-care products, it is used to reduce wrinkles and other effects of skin aging. [4] Retinol at normal doses is well tolerated. [1] High doses may cause enlargement of the liver, dry skin, and hypervitaminosis A. [1] [5] High doses during pregnancy may harm the fetus. [1]
Hypervitaminosis A refers to the toxic effects of ingesting too much preformed vitamin A (retinyl esters, retinol, and retinal). Symptoms arise as a result of altered bone metabolism and altered metabolism of other fat-soluble vitamins. Hypervitaminosis A is believed to have occurred in early humans, and the problem has persisted throughout ...
The use of topical retinoids should also be excluded during pregnancy and in women planning pregnancy. [citation needed] Many lotions that claim to prevent or treat stretch marks contain retinol, which is not an ingredient that is safe for pregnant women.
It’s characterized by dark blotchy patches, which typically appear on the face, and often appears during pregnancy — 15% to 50% of pregnant women get melasma, according to the Cleveland Clinic.
In support of this theory, ethanol-induced developmental defects can be ameliorated by increasing the levels of retinol or retinal. [30] As for the risks of too much RA during embryogenesis, the prescription drugs tretinoin (all-trans-retinoic acid) and isotretinoin (13-cis-retinoic acid), used orally or topically for acne treatment, are ...
Its effects on hormones are so pronounced that it is not recommended for treating acne in men because of its potentially feminizing side effects. ... Retinol: Many retinol products are available ...
“Women are waiting longer to have kids, and we’ve seen that pregnancy actually can decrease the risk of MS,” says Dr. Fabian. The biological changes that occur during pregnancy include ...
Other severe side effects include high white blood cell counts and blood clots. [8] Use during pregnancy is contraindicated due to the risk of birth defects. [8] [1] It is in the retinoid family of medications. [9] Tretinoin was patented in 1957 and approved for medical use in 1962. [13] It is on the World Health Organization's List of ...