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Pregnenolone, sold under the brand name Enelone among others, is a medication and supplement as well as a naturally occurring and endogenous steroid. [3] [1] [4] [5] [6] It is described as a neurosteroid and anti-inflammatory drug and was used in the treatment of rheumatoid arthritis and soft-tissue rheumatism in the 1950s and is no longer prescribed today, but remains available as a supplement.
Pregnenolone can be converted to 17α-hydroxypregnenolone by the enzyme 17α-hydroxylase . Using this pathway, termed Δ 5 pathway, the next step is conversion to dehydroepiandrosterone (DHEA) via 17,20-lyase (CYP17A1). DHEA is the precursor of androstenedione. Pregnenolone can be converted to androstadienol by 16-ene synthase (CYP17A1).
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If you’re looking to keep inflammation at bay, these are five supplements you should avoid, according to experts. Related: 5 Supplements You Shouldn't Take for Arthritis, According to Experts 1.
Pregnanolone, also known as 3α,5β-tetrahydroprogesterone (3α,5β-THP) or as 5β-pregnan-3α-ol-20-one, is a naturally occurring pregnane steroid and a derivative of progesterone.