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Inhaled salbutamol was banned from those games, but by 1986 was permitted (although oral β 2 agonists were not). After a steep rise in the number of athletes taking β 2 agonists for asthma in the 1990s, Olympic athletes were required to provide proof that they had asthma in order to be allowed to use inhaled β 2 agonists. [32]
They are both inhaled and given by aerosol delivery devices. [5] [6] Long-lasting β 2-agonists are often given in a combination with corticosteroids to treat asthma. Short-acting β 2-agonists are used to treat exercise-induced asthma, [7] and for asthma patients to get a quick relief of symptoms. They are taken 10–15 minutes before exercise.
Inhaled short-acting β2-adrenergic agonists, such as terbutaline and salbutamol, are the first-line drugs indicated for asthma exacerbation for all patients to provide rapid bronchodilating effects. [ 1 ] [ 2 ] Short-acting β2-adrenergic agonists can be delivered by different devices, for example, nebulizers and metered-dose inhalers .
Salbutamol metered dose inhaler commonly used to treat asthma attacks. Short-acting beta 2-adrenoceptor agonists (SABAs), such as salbutamol (albuterol USAN) are the first-line treatment for asthma symptoms. [7] They are recommended before exercise in those with exercise-induced symptoms. [188]
Salbutamol or albuterol and some other β 2 agonists, such as formoterol, also are sold in a solution form for nebulization, which is more commonly used than inhalers in emergency rooms. [9] Nebulizers continuously deliver aerosolized drug and salbutamol delivered through nebulizer was found to be more effective than IV administration. [10]
LABAs are designed to reduce the need for shorter-acting β 2 agonists such as salbutamol (albuterol), as they have an approximately twelve-hour duration of action, compared to about five hours for salbutamol, making them candidates for sparing high doses of corticosteroids [citation needed] or treating nocturnal asthma and providing ...