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David Matthews, a co-author for this study, clarified that MRC-5 was solely used for testing purposes to determine "how the Oxford vaccine behaves when it is inside a genetically normal human cell." [6] The manufacturing of the vaccine used the HEK 293 fetal cell line, the kidney cells of an aborted or spontaneously miscarried female fetus ...
WI-38 cells (Left: in high density. Right: in low density) WI-38 is a diploid human cell line composed of fibroblasts derived from lung tissue of a 3-month-gestation female fetus. [1] [2] The fetus came from the elective abortion of a Swedish woman in 1963.
The vaccines do not contain any of the original fetal tissue or cells or cells derived from fetal materials. [5] Although the vaccine materials are purified from cell debris, traces of human DNA fragments remain. [6] [7] [8] The cell lines continue to replicate on their own and no further sources of fetal cells are needed. [5]
WI-38 is now used for the production of all of the Rubella Virus vaccine used in the Western Hemisphere. WI-38, or new diploid cell strains, are used today for the manufacture of most human virus vaccines produced throughout the world including those for poliomyelitis, rubella, rubeola, varicella, mumps, rabies, adenoviruses and hepatitis A ...
To produce viral vaccines, candidate vaccine viruses are grown in mammalian, avian or insect tissue culture of cells with a finite lifespan. [5] These cells are typically Madin-Darby Canine Kidney cells, [6] but others are also used including monkey cell lines pMK and Vero and human cell lines HEK 293, MRC 5, Per.C6, PMK, and WI-38. [7]
A peptide vaccine candidate being developed in Germany is meant to induce a response in T cells, which… Some people, like many who are immunocompromised, may not have as strong of an immune ...
Human diploid cell rabies vaccines are inactivated vaccines made using the attenuated Pitman-Moore L503 strain of the virus. [23] In addition to these developments, newer and less expensive purified chicken embryo cell vaccines (CCEEV) and purified Vero cell rabies vaccines are now available and are recommended for use by the WHO. [11]
Rubella vaccine is a vaccine used to prevent ... The vaccine was attenuated and prepared in the WI-38 normal human diploid cell strain which was developed by ...