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2. Melatonin as a medication and supplement - Wikipedia

   en.wikipedia.org/wiki/Melatonin_as_a_medication...

   Melatonin appears to be relatively safe in overdose. [8] It has been administered at daily doses of up to 300 mg without causing clinically significant adverse reactions in the literature. [8] The most commonly reported adverse effect of melatonin overdose is somnolence. [8]

3. Melatonin - Wikipedia

   en.wikipedia.org/wiki/Melatonin

   In humans, ~30 μg of melatonin is produced daily and 80% of the total amount is produced in the night (W). The plasma maximum concentration of melatonin at night are 80–120 pg/mL and the concentrations during the day are between 10–20 pg/mL. [76] [77]

4. The 6 best melatonin supplements - AOL

   www.aol.com/6-best-melatonin-supplements...

   This Natrol liquid melatonin, which contains 1 milligram of melatonin per 4-milliliter serving, can be taken on its own or added to water or juice.The recommended dose is 4 milligrams, but it’s ...

5. Therapeutic index - Wikipedia

   en.wikipedia.org/wiki/Therapeutic_index

   For many drugs, severe toxicities in humans occur at sublethal doses, which limit their maximum dose. A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug.

6. Taking melatonin for sleep? What to know about potential ...

   www.aol.com/news/taking-melatonin-sleep-know...

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7. Is melatonin or ashwagandha better for sleep? Experts weigh in

   www.aol.com/finance/melatonin-ashwagandha-better...

   For those who wake up in the middle of the night, he recommends a sustained release of a higher dose of melatonin. To reap the sleep benefits of ashwagandha, he says the supplement must be at ...