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Terbutaline, sold under the brand names Bricanyl and Marex among others, is a β 2 adrenergic receptor agonist, used as a "reliever" inhaler in the management of asthma symptoms and as a tocolytic (anti-contraction medication) to delay preterm labor for up to 48 hours.
Beta 2-adrenergic agonists, also known as adrenergic β 2 receptor agonists, are a class of drugs that act on the β 2 adrenergic receptor. Like other β adrenergic agonists , they cause smooth muscle relaxation. β 2 adrenergic agonists' effects on smooth muscle cause dilation of bronchial passages , vasodilation in muscle and liver ...
Administration of higher doses of short-acting β 2-agonists increases duration of action but also increases side effects such as cardiac effects. One approach to avoid these side effects is to use structurally different features that may minimize absorption into systemic circulation. For example, one could use drugs that transform into ...
As terbutaline is selective to β2 receptors, it has relatively less effect on the heart, preventing heart-related side effects. [12] Side effects of terbutaline includes peripheral vasodilation, tremor due to stimulation of β2 receptors in skeletal muscle, and tachycardia due to slight effect on β1 receptors. [13]
Other side effects include headaches and essential tremor. Hypoglycemia was also reported due to increased secretion of insulin in the body from activation of β 2 receptors. [citation needed] In 2013, zilpaterol, a β agonist sold by Merck, was temporarily withdrawn due to signs of sickness in some cattle that were fed the drug. [8]
Safer than both nifedipine and beta agonists; As effective as nifedipine and more effective than beta agonists. [29] Fewer side effects than β 2 agonists. [30] Although not FDA approved in the US, atosiban was developed specifically to delay preterm labor. [31] No current contraindications No maternal adverse effects [32]
Bambuterol is a long-acting β adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline. Commercially, the AstraZeneca pharmaceutical company produces and markets bambuterol as Bambec and Oxeol .
Ritodrine is a short-acting β 2-adrenoreceptor agonist — a class of medication used for smooth muscle relaxation (other similar drugs are used in asthma or other pulmonary diseases such as salbutamol (albuterol)). Since ritodrine has a bulky N-substituent, it has high β 2-adrenergic receptor selectivity.