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Lysosome. Centrosome. Cell membrane. A lysosome (/ ˈlaɪsəˌsoʊm /) is a single membrane-bound organelle found in many animal cells. [1][2] They are spherical vesicles that contain hydrolytic enzymes that digest many kinds of biomolecules. A lysosome has a specific composition, of both its membrane proteins and its lumenal proteins.
Vesicle (biology and chemistry) Scheme of a liposome formed by phospholipids in an aqueous solution. In cell biology, a vesicle is a structure within or outside a cell, consisting of liquid or cytoplasm enclosed by a lipid bilayer. Vesicles form naturally during the processes of secretion (exocytosis), uptake (endocytosis), and the transport of ...
Lysosomes break down the LDL into cholesterol and other lipids (fatty acids), hence LDL-derived cholesterol. The epididymal secretory protein E1 (NPC2) is produced via transcription of the NPC2 gene and recruits and transfers the LDL-derived cholesterol to the sterol-binding pocket in the N-terminal domain of the NPC1 protein to be transferred ...
The endomembrane system is composed of the different membranes (endomembranes) that are suspended in the cytoplasm within a eukaryotic cell. These membranes divide the cell into functional and structural compartments, or organelles. In eukaryotes the organelles of the endomembrane system include: the nuclear membrane, the endoplasmic reticulum ...
Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of the endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can follow this pathway all the way to lysosomes for degradation or can be recycled back to the cell ...
Autophagy (or autophagocytosis; from the Ancient Greek αὐτόφαγος, autóphagos, meaning "self-devouring" [1] and κύτος, kýtos, meaning "hollow") [2] is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. [3] It allows the orderly ...
Autolysis (biology) In biology, autolysis, more commonly known as self-digestion, refers to the destruction of a cell through the action of its own enzymes. It may also refer to the digestion of an enzyme by another molecule of the same enzyme. The term derives from the Greek αὐτο- 'self' and λύσις 'splitting'.
The primary function of lysosomal lipase is to hydrolyze lipids such as triglycerides and cholesterol. [1] These fats are transported and degraded into free fatty acids. Lysosomal lipases function optimally at an acidic pH which are complementary with the environment found in the lysosomal lumen. [2] These enzymes were believed to only ...