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  2. Bone marrow - Wikipedia

    en.wikipedia.org/wiki/Bone_marrow

    Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones. [2] In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). [3] It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells.

  3. Megakaryocyte - Wikipedia

    en.wikipedia.org/wiki/Megakaryocyte

    A megakaryocyte (from mega- 'large' karyo- ' cell nucleus ' and -cyte ' cell ') is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes), which are necessary for normal clotting. In humans, megakaryocytes usually account for 1 out of 10,000 bone marrow cells, but can increase in number nearly 10-fold ...

  4. Extramedullary hematopoiesis - Wikipedia

    en.wikipedia.org/wiki/Extramedullary_hematopoiesis

    Extramedullary hematopoiesis. Micrograph showing nucleated red blood cells (bottom left of image), one of the elements necessary to call extramedullary hematopoiesis, in an endometrial polyp. H&E stain. Extramedullary hematopoiesis (EMH or sometimes EH[1]) refers to hematopoiesis occurring outside of the medulla of the bone (bone marrow). [2]

  5. Granulopoiesis - Wikipedia

    en.wikipedia.org/wiki/Granulopoiesis

    A granulocyte, also referred to as a polymorphonuclear leukocyte (PMN), is a type of white blood cell that has multi lobed nuclei, usually containing three lobes, and has a significant amount of cytoplasmic granules within the cell. [ 1 ] Granulopoiesis takes place in the bone marrow. [ 2 ] It leads to the production of three types of mature ...

  6. CD34 - Wikipedia

    en.wikipedia.org/wiki/CD34

    Cells expressing CD34 (CD34 + cell) are normally found in the umbilical cord and bone marrow as haematopoietic cells, or in endothelial progenitor cells, endothelial cells of blood vessels but not lymphatics (except pleural lymphatics), mast cells, a sub-population of dendritic cells (which are factor XIIIa-negative) in the interstitium and around the adnexa of dermis of skin, as well as cells ...

  7. Acute myeloid leukemia - Wikipedia

    en.wikipedia.org/wiki/Acute_myeloid_leukemia

    Deaths. 147,100 (2015) [5] Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. [1] Symptoms may include feeling tired, shortness of breath, easy bruising and bleeding, and ...

  8. Thrombopoiesis - Wikipedia

    en.wikipedia.org/wiki/Thrombopoiesis

    Thrombopoiesis is the formation of thrombocytes (blood platelets) in the bone marrow. Thrombopoietin is the main regulator of thrombopoiesis. Thrombopoietin affects most aspects of the production of platelets. This includes self-renewal and expansion of hematopoietic stem cells, stimulating the increase of megakaryocyte progenitor cells, and ...

  9. Fanconi anemia - Wikipedia

    en.wikipedia.org/wiki/Fanconi_anemia

    Fanconi anemia (FA) is a rare, autosomal recessive, genetic disease resulting in impaired response to DNA damage in the FA/BRCA pathway. Although it is a very rare disorder, study of this and other bone marrow failure syndromes has improved scientific understanding of the mechanisms of normal bone marrow function and development of cancer.