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High-dose supplements of antioxidants may be linked to health risks in some cases, including higher mortality rates. For example, high doses of beta-carotene and vitamin E was found to increase the risk of lung cancer and overall mortality in smokers. [2] High doses of vitamin E may increase risks of prostate cancer and one type of stroke.
Antioxidants & Redox Signaling is a peer-reviewed scientific journal covering reduction–oxidation (redox) signaling and antioxidant research. It covers topics such as reactive oxygen species/reactive nitrogen species (ROS/RNS) as messengers gaseous signal transducers, hypoxia and tissue oxygenation, microRNA, prokaryotic systems, and lessons from plant biology.
In her further research on cancer chemotherapy, she explored how cisplatin selectively kills proximal tubule cells, identified its metabolic pathway to a nephrotoxin, and showed that the metabolism in these cells is crucial for cisplatin-induced kidney damage, suggesting new targets for inhibition.
Antioxidants is a peer-reviewed open-access scientific journal that covers various areas of antioxidants research, including biosynthesis, pharmacodynamics, and synthetic antioxidants. It is published by MDPI and was established in 2012. The editor-in-chief is Stanley Omaye (University of Nevada).
Antioxidants are helpful in reducing and preventing damage from free radical reactions because of their ability to donate electrons which neutralize the radical without forming another. Vitamin C , for example, can lose an electron to a free radical and remain stable itself by passing its unstable electron around the antioxidant molecule.
The hope is that future research into TIGAR will provide insight into new ways to treat cancer. [ 8 ] [ 9 ] [ 10 ] This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate.
Although research in vitro indicates polyphenols are good antioxidants and probably influence the ORAC value, antioxidant effects in vivo are probably negligible or absent. [3] [10] By non-antioxidant mechanisms still undefined, flavonoids and other polyphenols may reduce the risk of cardiovascular disease and cancer. [11]
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]