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Monocytes are a type of leukocyte or white blood cell. They are the largest type of leukocyte in blood and can differentiate into macrophages and monocyte-derived dendritic cells . As a part of the vertebrate innate immune system monocytes also influence adaptive immune responses and exert tissue repair functions.
A white blood cell differential is a medical laboratory test that provides information about the types and amounts of white blood cells in a person's blood. The test, which is usually ordered as part of a complete blood count (CBC), measures the amounts of the five normal white blood cell types – neutrophils, lymphocytes, monocytes, eosinophils and basophils – as well as abnormal cell ...
An excess of white blood cells is usually due to infection or inflammation. Less commonly, a high white blood cell count could indicate certain blood cancers or bone marrow disorders. The number of leukocytes in the blood is often an indicator of disease, and thus the white blood cell count is an important subset of the complete blood count.
The image on the left shows a monocyte actively phagocytizing an antibody-sensitized red blood cell. The image on the right shows multiple RBC that have been phagocytized by a single monocyte. The monocyte monolayer assay (MMA) is used to determine the clinical significance of alloantibodies produced by blood transfusion recipients. [1]
A peripheral blood mononuclear cell (PBMC) is any peripheral blood cell having a round nucleus. [1] These cells consist of lymphocytes (T cells, B cells, NK cells) and monocytes, whereas erythrocytes and platelets have no nuclei, and granulocytes (neutrophils, basophils, and eosinophils) have multi-lobed nuclei. In humans, lymphocytes make up ...
This is a list of immune cells, also known as white blood cells, white cells, leukocytes, or leucocytes. They are cells involved in protecting the body against both infectious disease and foreign invaders .
Rather than quantify biomarkers which are present in blood, MONCYTE Health quantifies the cellular processes that affect the biomarkers. This unique insight provides the possibility to predict an optimal treatment strategy and to overcome current approaches of trying out different medications over time.
Monocytes will then develop into macrophages or dendritic cells upon tissue damage and recruitment of monocytes into the infected area. [1] During recruitment monocytes are distinct from macrophages and dendritic cells, but upon entering the infected area, monocytes will acquire inflammatory effector functions and then differentiate into ...