Search results
Results From The WOW.Com Content Network
Half maximal inhibitory concentration (IC 50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function. IC 50 is a quantitative measure that indicates how much of a particular inhibitory substance (e.g. drug) is needed to inhibit, in vitro, a given biological process or biological component by 50%. [1]
Half maximal effective concentration (EC 50) is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time. [1] More simply, EC 50 can be defined as the concentration required to obtain a 50% [...] effect [2] and may be also written ...
For antagonists, half maximal inhibitory concentration (IC50) is used to measure the potency of antagonists. IC50 means the concentration of antagonist needed to give a 50% inhibition. [30] It can be directly compared with EC50, which is commonly used to measure the potency of an agonist.
5α-RIs that were under development for potential clinical use but were never marketed or are used in research include the following: 4-MA – inhibits types 1 and 2 (IC 50 Tooltip half-maximal inhibitory concentration = 8.5 nM), but also 3β-HSD Tooltip 3β-hydroxysteroid dehydrogenase inhibitor, investigated extensively but found to be hepatotoxic [1]
It is a measure of the concentration of a drug, antibody or toxicant which induces a biological response halfway between the baseline and maximum after a specified exposure time. In other words, it can be defined as the concentration required to obtain a 50% effect. [3] Half maximal inhibitory concentration
In addition to its MRA activity, 4-MTDMA is a fairly potent monoamine oxidase A (MAO-A) inhibitor, with an IC 50 Tooltip half-maximal inhibitory concentration of 2,100 nM. [4] [5] Potent monoamine oxidase inhibition by amphetamines has been associated with dangerous and sometimes fatal toxicity in humans. [4] [5]
Half-maximal concentration can refer to either of the following: EC 50 - half-maximal effective concentration; IC 50 - half-maximal inhibitory concentration
The next step is to generate a kill curve which defines the ideal concentration of a selection antibiotic to kill untransfected cells (Fig 1A). Curves are generated for both sensitive cells and resistant cells. The half-maximal Inhibitory Concentration can be calculated, which measures the potency of the antibiotic.