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Waldmann's disease, Primary intestinal lymphangiectasia Waldmann disease, also known as Primary Intestinal Lymphangiectasia (PIL), is a rare disease [ 1 ] characterized by enlargement of the lymph vessels supplying the lamina propria of the small intestine . [ 2 ]
Lymphangiectasia, also known as "lymphangiectasis", [1] is a pathologic dilation of lymph vessels. [2] When it occurs in the intestines it is known as intestinal lymphangiectasia, colloquially recognized as Waldmann's disease in cases where there is no secondary cause. [3]
Infants may present with feeding difficulties with frequent vomiting, diarrhea, swelling of the abdomen, and failure to gain weight or sometimes weight loss. [2]As the disease progresses in infants, increasing fat accumulation in the liver leads to other complications including yellowing of the skin and whites of the eyes (), and a persistent low-grade fever.
Thomas A. Waldmann (21 September 1930 – 25 September 2021) was an American immunologist who has worked on therapeutic monoclonal antibodies to the IL-2 receptor, Interleukin 15 (IL-15), and Adult T-cell Leukemia (ATL). Until the week he died, he was an active distinguished investigator at the Lymphoid Malignancies Branch of the National ...
Weber–Christian disease; Webster–Deming syndrome; Wegener's granulomatosis (now known as granulomatosis with polyangiitis) Wegmann–Jones–Smith syndrome; Weil syndrome; Weinstein–Kliman–Scully syndrome; Weismann–Netter–Stuhl syndrome; Weissenbacher–Zweymuller syndrome; Welander distal myopathy, Swedish type; Weleber–Hecht ...
The signs and symptoms of protein losing enteropathy include diarrhea, fever, and general abdominal discomfort. [4] Swelling of the legs due to peripheral edema can also occur; however, if the PLE is related to a systemic disease such as congestive heart failure or constrictive pericarditis, then these symptoms could be due directly to the underlying illness. [2]
Lymphadenopathy or adenopathy is a disease of the lymph nodes, in which they are abnormal in size or consistency.Lymphadenopathy of an inflammatory type (the most common type) is lymphadenitis, [1] producing swollen or enlarged lymph nodes.
Herman Waldmann FRS FMedSci (born 27 February 1945) is a British immunologist known for his work on therapeutic monoclonal antibodies. As of 2013, he is Emeritus Professor of Pathology at the Sir William Dunn School of Pathology at the University of Oxford .