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The term hemochromatosis was initially used to refer to what is now more specifically called hemochromatosis type 1 (or HFE-related hereditary hemochromatosis). Currently, hemochromatosis (without further specification) is mostly defined as iron overload with a hereditary or primary cause, [11] [12] or originating from a metabolic disorder. [13]
There are five types of hereditary hemochromatosis: type 1, 2 (2A, 2B), 3, 4 [9] and 5, [10] all caused by mutated genes. Hereditary hemochromatosis type 1 is the most frequent, and uniquely related to the HFE gene. It is most common among those of Northern European ancestry, in particular those of Celtic descent. [11]
They display only slight iron loading on a normal diet, but accumulates iron when fed a high-iron diet. [12] The probable cause of African iron overload is the combination of excess iron intake and functional changes in ferroportin. [4] [5] Penetrance of Q248H as a cause of iron overload is most likely low. [4] [11]
(Note: Hemochromatosis, a.k.a. iron overload, can occur for genetic reasons or due to factors like history of diabetes, alcohol abuse, and more, per Cleveland Clinic). How To Try The Iron Fish ...
Iron-rich foods include shrimp, broccoli, eggs, chicken, wheat products, raisins and cashews, to name a few. FYI: Signs of iron overload include fatigue, an irregular heartbeat , joint pain ...
The gene involved with patients diagnosed with type 3 hemochromatosis is TFR2 ( or HFE3). HFE (not the same as HFE3) is most often the cause of hereditary hemochromatosis. [14] The HFE gene provides instructions for producing a protein that is located on the surface of cells, primarily liver and intestinal cells.
For instance, a severe form of iron overload, juvenile hemochromatosis, is a result of severe hepcidin deficiency. The majority of cases are caused by mutations in the hemojuvelin gene (HJV or RGMc/repulsive guidance molecule c). The exceptions, people who have mutations in the gene for ferroportin, prove the rule: these people have plenty of ...
People with increased amounts of iron, as, for example, in hemochromatosis, are more susceptible to some bacterial infections. [6] Although this mechanism is an elegant response to short-term bacterial infection, it can cause problems when it goes on so long that the body is deprived of needed iron for red cell production.
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