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Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that contains the pyrimidine base cytosine. The triphosphate group contains high-energy phosphoanhydride bonds, which liberate energy when hydrolized. DNA polymerase enzymes use this energy to incorporate deoxycytidine into a newly synthesized strand of DNA.
In enzymology, a dCTP diphosphatase (EC 3.6.1.12) is an enzyme that catalyzes the chemical reaction dCTP + H 2 O ⇌ {\displaystyle \rightleftharpoons } dCMP + diphosphate Thus, the two substrates of this enzyme are dCTP and H 2 O , whereas its two products are dCMP and diphosphate .
Deoxycytidine diphosphate is a nucleoside diphosphate.It is related to the common nucleic acid CTP, or cytidine triphosphate, with the -OH group on the 2' carbon on the nucleotide's pentose removed (hence the deoxy- part of the name), and with one fewer phosphoryl group than CTP .
In enzymology, a dCTP deaminase (EC 3.5.4.13) is an enzyme that catalyzes the chemical reaction dCTP + H 2 O ⇌ {\displaystyle \rightleftharpoons } dUTP + NH 3 Thus, the two substrates of this enzyme are dCTP and H 2 O , whereas its two products are dUTP and NH 3 .
66422 Ensembl ENSG00000179958 ENSMUSG00000042462 UniProt Q9H773 Q9QY93 RefSeq (mRNA) NM_024096 NM_023203 RefSeq (protein) NP_077001 NP_075692 Location (UCSC) Chr 16: 30.42 – 30.43 Mb Chr 7: 126.86 – 126.86 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse dCTP pyrophosphatase 1 is an enzyme that in humans is encoded by the DCTPP1 gene. See also Deoxycytidine triphosphate (dCTP ...
Cytidine triphosphate (CTP) is a pyrimidine nucleoside triphosphate.CTP, much like ATP, consists of a ribose sugar, and three phosphate groups.The major difference between the two molecules is the base used, which in CTP is cytosine.
Thymidine diphosphate (TDP) or deoxythymidine diphosphate (dTDP) (also thymidine pyrophosphate, dTPP) is a nucleotide diphosphate.It is an ester of pyrophosphoric acid with the nucleoside thymidine. dTDP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase thymine.
Deoxycytidine monophosphate is a molecule of interest in treating genetic disorders such as thymidine kinase 2 (TK2) deficiency.In the case of TK2 deficiency, dCMP in conjunction with deoxythymidine monophosphate (dTMP) to bypass the deficiency in the TK2 enzyme. [2]