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A 2018 pooled analysis from three phase III, randomized, double-blind, placebo-controlled studies on usage for Opioid-Induced Constipation, found that the numbers of patients reporting adverse effects were similar in both the lubiprostone and placebo treatment groups for all opioid classes (P ≥ 0.125); however, gastrointestinal adverse ...
Plecanatide, sold under the brand name Trulance, is a medication for the treatment of chronic idiopathic constipation (CIC) [4] and irritable bowel syndrome with constipation. [5] It is available in India under the brand name Plectide (OQM Div, MSN Laboratories, India). Plecanatide is an agonist of guanylate cyclase-C.
AMITIZA is approved in the United States for the treatment of two constipation-related indications, and in Switzerland and the United Kingdom for one constipation-related indication.
U.S. Food and Drug Administration Grants Priority Review Status to AMITIZA ® (lubiprostone) Submission Seeking Approval for Treatment of Opioid-induced Constipation BETHESDA, Md. & DEERFIELD, Ill ...
Sucampo Receives $15 Million Milestone Payment from Abbott on First Sale of AMITIZA ® (lubiprostone) in Japan AMITIZA is First-ever Approved Prescription Medicine for Chronic Constipation in ...
A number of novel therapeutic treatments have been suggested and licensed in recent years for the treatment of functional constipation. [13] Prosecretory drugs including plecanatide, linaclotide, and lubiprostone alter gut epithelial channels, encouraging intestinal fluid secretion and increasing stool volume, which improves GI transit. [17]