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The eIF4A translation initiation factor was the first DEAD box protein found to have an RNA-dependent ATPase activity. It has been proposed that this abundant protein helps in unwinding the secondary structure in the 5'-untranslated region. [17] This can inhibit the scanning process of the small ribosomal subunit, if not unwound. [17]
[58] [59] All the eukaryotic RNA helicases that have been identified up to date are non-ring forming and are part of SF1 and SF2. On the other hand, ring-forming RNA helicases have been found in bacteria and viruses. [56] However, not all RNA helicases exhibit helicase activity as defined by enzymatic function, i.e., proteins of the Swi/Snf family.
104721 Ensembl ENSG00000079785 ENSMUSG00000037149 UniProt Q92499 Q91VR5 RefSeq (mRNA) NM_004939 NM_134040 RefSeq (protein) NP_004930 NP_598801 Location (UCSC) Chr 2: 15.59 – 15.63 Mb Chr 12: 13.27 – 13.3 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ATP-dependent RNA helicase DDX1 is an enzyme that in humans is encoded by the DDX1 gene. Function DEAD box proteins, characterized ...
Certain viruses cleave a portion of eIF4G that binds eIF4E, thus preventing cap-dependent translation to hijack the host machinery in favor of the viral (cap-independent) messages. eIF4A is an ATP-dependent RNA helicase that aids the ribosome by resolving certain secondary structures formed along the mRNA transcript. Recent structural biology ...
DEAD box proteins are putative RNA helicases characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution ...
The mRNA cap is bound by eIF4E (25 kDa), eIF4G (185 kDa) acts as a scaffold for the complex whilst the ATP-dependent RNA helicase eIF4A (46 kDa) processes the secondary structure of the mRNA 5’ UTR to render it more conducive to ribosomal binding and subsequent translation. [10] Together these three proteins are referred to as eIF4F.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases.They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
9188 56200 Ensembl ENSG00000165732 ENSMUSG00000020075 UniProt Q9NR30 Q9JIK5 RefSeq (mRNA) NM_001256910 NM_004728 NM_019553 RefSeq (protein) NP_001243839 NP_004719 NP_062426 Location (UCSC) Chr 10: 68.96 – 68.99 Mb Chr 10: 62.42 – 62.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nucleolar RNA helicase 2 is an enzyme that in humans is encoded by the DDX21 gene. Function DEAD ...