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Myasthenia gravis is an autoimmune disease of the neuromuscular junction which results from antibodies that block or destroy nicotinic acetylcholine receptors (AChR) at the junction between the nerve and muscle. [6][7][1] This prevents nerve impulses from triggering muscle contractions. [1]
Myasthenia gravis is caused by autoantibodies to the postsynaptic acetylcholine receptors. Lambert–Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder characterized by muscle weakness of the limbs. It is also known as myasthenic syndrome, Eaton–Lambert syndrome, and when related to cancer, carcinomatous myopathy.
Eculizumab, sold under the brand name Soliris among others, is a recombinant humanized monoclonal antibody used to treat paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, generalized myasthenia gravis, and neuromyelitis optica. [8][9] In people with paroxysmal nocturnal hemoglobinuria, it reduces both the destruction of ...
The company is testing its drug, inebilizumab or Uplizna, in patients suffering from myasthenia gravis, which is caused by an abnormal immune reaction that weakens the muscles that control the ...
Rare. Transient neonatal myasthenia gravis, i.e., TNMG (also termed neonatal myasthenia gravis [1]), and its more severe form, fetal acetylcholine receptor inactivation syndrome (i.e., FARIS), is one of the various types of myasthenia gravis (i.e., MG). [2] MG is an autoimmune disease in which individuals form antibodies that circulate in their ...
Myasthenia gravis is caused most commonly by auto-antibodies against the acetylcholine receptor. It has recently been realized that a second category of gravis is due to auto-antibodies against MuSK. A different condition, Lambert–Eaton myasthenic syndrome, is usually associated with presynaptic antibodies to the voltage-dependent calcium channel
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