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There are 370 drugs known to interact with metformin, along with 5 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 24 are major, 337 are moderate, and 9 are minor.
Taking metformin with certain medications and substances can result in worsened side effects or reduce metformin’s effectiveness. Below, we review seven important metformin drug interactions to be aware of.
Metformin has many drug-disease interactions that can increase the risk of MALA. Metformin may increase lactic acid production from the splanchnic tissues slightly, but MALA occurs in the setting of comorbid diseases that increase systemic levels of lactic acid or reduce elimination of metformin.
370 medications are known to interact with metformin. Includes: drug, food, pregnancy, breastfeeding and therapeutic duplication warnings.
Does metformin interact with other medicines (drug interactions)? Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals,...
Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis), decreasing the intestinal absorption of glucose, and increasing insulin sensitivity by increasing peripheral glucose uptake and utilization. 23 It is well established that metformin inhibits mitochondrial complex I activity, and it ...
Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question.
Interactions. 1. How it works. Metformin may be used to treat Type 2 diabetes. Metformin increases the ability of cells to uptake glucose by improving their insulin sensitivity. It also works by decreasing the amount of glucose made by the liver and decreasing the absorption of glucose from the intestine.
What other drugs will affect metformin? Many drugs can interact with metformin, making it less effective or increasing your risk of lactic acidosis. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.
Relevant drug interactions are predominantly related to sulfonylureas, thiazolidinediones and glinides. Although metformin has a very low interaction potential, caution is advised when drugs that impair renal function are used concomitantly.