Search results
Results From The WOW.Com Content Network
Nicolaou Taxol total synthesis overview from raw material perspective. The Nicolaou Taxol total synthesis, published by K. C. Nicolaou and his group in 1994 concerns the total synthesis of taxol. [1] Taxol is an important drug in the treatment of cancer but also expensive because the compound is harvested from a scarce resource, namely the ...
Drug titration is the process of adjusting the dose of a medication for the maximum benefit without adverse effects. [ 1 ] When a drug has a narrow therapeutic index , titration is especially important, because the range between the dose at which a drug is effective and the dose at which side effects occur is small. [ 2 ]
Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). [1] This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew ( Taxus brevifolia ).
Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. [11] It is administered by intravenous injection. [11] There is also an albumin-bound formulation. [11]
Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. [ 2 ] [ 3 ] Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer . Taxanes present difficulties in formulation as medicines because they are poorly soluble in water.
When chemotherapy was introduced in the 1950s, the BSA formula was adopted as the official standard for chemotherapy dosing for lack of a better option. [18] [19] The validity of this method in calculating uniform doses has been questioned because the formula only takes into account the individual's weight and height.
Takahashi Taxol total synthesis. The Takahashi Taxol total synthesis published by Takashi Takahashi in 2006 is one of several methods in taxol total synthesis. [1] The method starts from geraniol and differs from the other 6 published methods that it is a formal synthesis (the final product is baccatin III which lacks the amide tail found in taxol itself) and that it is racemic (the product ...
Holton Taxol total synthesis overview from raw material perspective. The Holton Taxol total synthesis, published by Robert A. Holton and his group at Florida State University in 1994, was the first total synthesis of Taxol (generic name: paclitaxel). [1] [2] The Holton Taxol total synthesis is a good example of a linear synthesis.