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Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. [ 5 ] [ 6 ] [ 7 ] It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors . [ 8 ]
Medical treatments include baclofen, diazepam and dantrolene which is a muscle-relaxant. Dantrolene has many side effects and as such, it is usually not the first choice in treatment of spasticity. The side effects include dizziness, nausea and weakness. [13]
Common side effects include low blood pressure, increased saliva production, muscle pain, and rash. [7] Serious side effects include malignant hyperthermia , hyperkalemia and allergic reactions . [ 8 ] [ 9 ] It is not recommended in people who are at risk of high blood potassium or a history of myopathy . [ 6 ]
While some added sugar can be part of a balanced diet, consuming excess amounts of added sugar has been linked with negative effects on gut health and insulin resistance, both of which can ...
Dantrolene sodium, the only available medical treatment for malignant hyperthermia The current treatment of choice is the intravenous administration of dantrolene , the only known antidote, discontinuation of triggering agents, and supportive therapy directed at correcting hyperthermia, acidosis, and organ dysfunction.
Documented side effects include: Short-term water retention. Gastric distress. Muscle cramping. Dehydration. Some side effects may be more likely with larger doses and hot environments.
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
Dantrolene, although thought of primarily as a peripherally acting agent, is associated with CNS effects, whereas baclofen activity is strictly associated with the CNS. Muscle relaxants are thought to be useful in painful disorders based on the theory that pain induces spasm and spasm causes pain.