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Microphthalmia is a congenital disorder in which the globe of the eye is unusually small and structurally disorganized. [2] [4] While the axis of an adult human eye has an average length of about 23.8 mm (0.94 in), a diagnosis of microphthalmia generally corresponds to an axial length below 21 mm (0.83 in) in adults.
An epicanthic fold or epicanthus [6] is a skin fold of the upper eyelid that covers the inner corner (medial canthus) of the eye. [3] However, variation occurs in the nature of this feature and the possession of "partial epicanthic folds" or "slight epicanthic folds" is noted in the relevant literature.
Other common symptoms include lack of an eyelid fold, an appearance of widely spaced eyes (telecanthus), low nose bridge and ear malformations (including cupping and incomplete development). Rare symptoms include microphthalmos (abnormally small eyes), tear ducts in the wrong location and a high-arched palate . [ 1 ]
Blepharophimosis forms a part of blepharophimosis, ptosis, epicanthus inversus syndrome (BPES), also called blepharophimosis syndrome, which is an autosomal dominant condition characterised by blepharophimosis, ptosis (upper eyelid drooping), epicanthus inversus (skin folds by the nasal bridge, more prominent lower than upper lid) and telecanthus (widening of the distance between the inner ...
The fissure may be increased in vertical height in Graves' disease, which is manifested as Dalrymple's sign.It is seen in disorders such as cri-du-chat syndrome. In animal studies using four times the therapeutic concentration of the ophthalmic solution latanoprost, the size of the palpebral fissure can be increased.
The pupil of the human eye can range in size from 2 mm to over 8 mm to adapt to the environment. The human eye can detect a luminance from 10 −6 cd/m 2, or one millionth (0.000001) of a candela per square meter to 10 8 cd/m 2 or one hundred million (100,000,000) candelas per square meter.
Carpenter syndrome has been associated with mutations in the RAB23 gene, [7] which is located on chromosome 6 in humans. Additionally, three key SNPs in the MEGF8 gene, [ 8 ] located on chromosome 19 at 19q13.2, have been identified as primary causes of Carpenter syndrome.
A constriction response , [2] is the narrowing of the pupil, which may be caused by scleral buckles or drugs such as opiates/opioids or anti-hypertension medications. Constriction of the pupil occurs when the circular muscle , controlled by the parasympathetic nervous system (PSNS), contracts, and also to an extent when the radial muscle relaxes.