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2. Exome sequencing - Wikipedia

   en.wikipedia.org/wiki/Exome_sequencing

   Exome sequencing workflow: part 1. Exome sequencing, also known as whole exome sequencing (WES), is a genomic technique for sequencing all of the protein-coding regions of genes in a genome (known as the exome). [1] It consists of two steps: the first step is to select only the subset of DNA that encodes proteins.

3. Off-target genome editing - Wikipedia

   en.wikipedia.org/wiki/Off-target_genome_editing

   In comparison, a 2016 whole exome sequencing study found 19 SNVs and 3 indels in 5 edited mice, while Schaefer et al. found 115 exonic SNVs and 9 indels in just 2 edited mice. [68] Many experts disagreed with the paper and criticized it through journal articles [ 68 ] and social media, suggesting that unusual CRISPR treatments were used in the ...

4. Exome - Wikipedia

   en.wikipedia.org/wiki/Exome

   Whole-exome sequencing is a recent technology that has led to the discovery of various genetic disorders and increased the rate of diagnoses of patients with rare genetic disorders. Overall, whole-exome sequencing has allowed healthcare providers to diagnose 30–50% of patients who were thought to have rare Mendelian disorders.

5. Molecular Inversion Probe - Wikipedia

   en.wikipedia.org/wiki/Molecular_Inversion_Probe

   Captured target identification; The captured target can be identified either via array-based hybridization approaches [3] or by sequencing of the target. [5] If array-based approach is used, the probe may optionally contain a probe-specific tag that uniquely identifies the probe as well as the genomic region targeted by it.

6. Tumor mutational burden - Wikipedia

   en.wikipedia.org/wiki/Tumor_mutational_burden

   For instance, targeted panels may enable deeper sequencing compared to whole exome sequencing, enabling higher sensitivity, that have been shown to perform well even when tumor cell content is low (defined as <10%). [22] Targeted panels have shown to enable much greater coverage than in whole exome sequencing. [22]

7. Personalized genomics - Wikipedia

   en.wikipedia.org/wiki/Personalized_Genomics

   Brief work flow of whole exome sequencing; DNA double strands are first digested in to single strands. Coding area (exon) and non-coding area (intron) are differentiated, and linear DNA are fragmented into the genomic DNA. Hybridization on capture array for target (coding area) enrichment. Finally, assayed by DNA sequencing program.