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Nephronophthisis is a genetic disorder of the kidneys which affects children. [3] It is classified as a medullary cystic kidney disease.The disorder is inherited in an autosomal recessive fashion and, although rare, is the most common genetic cause of childhood kidney failure.
Abnormal kidney function may cause too much or too little urine to be produced. The ability of the kidneys to filter protein is often measured, as urine albumin or urine protein levels, [ 2 ] measured either at a single instance or, because of variation throughout the day, as 24-hour urine tests.
Chronic kidney disease; Other names: Chronic renal disease, kidney failure, impaired kidney function [1] Illustration of a kidney from a person with chronic renal failure: Specialty: Nephrology: Symptoms: Early: None [2] Later: Leg swelling, feeling tired, vomiting, loss of appetite, confusion [2] Complications: Heart disease, high blood ...
Very low levels of azotemia may produce few, if any, symptoms. If the disease progresses, symptoms become noticeable (if the failure is of sufficient degree to cause symptoms). Kidney failure accompanied by noticeable symptoms is termed uraemia. [18] Symptoms of kidney failure include the following: [18] [19] [20] [21]
It is used when the kidneys are not working well, which is called kidney failure and includes acute kidney injury and chronic kidney disease. Renal replacement therapy includes dialysis ( hemodialysis or peritoneal dialysis ), hemofiltration , and hemodiafiltration , which are various ways of filtration of blood with or without machines.
Proper kidney function depends upon adequate blood flow to the kidney. Kidney blood flow is a complex, tightly regulated process that relies on a number of hormones and other small molecules, such as prostaglandins. Under normal circumstances, prostaglandin E2 (PGE 2) produced by the kidney is necessary to support adequate blood flow to the kidney.
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