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Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
[10] [11] Two notable protein phosphatases are PP2A and PP2B. PP2A is involved in multiple regulatory processes, such as DNA replication, metabolism, transcription, and development. PP2B, also called calcineurin, is involved in the proliferation of T cells; because of this, it is the target of some drugs that seek to suppress the immune system. [9]
"HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359– 370. doi: 10.1006/viro.2001.1007. PMID 11531413. Li X, Virshup DM (2002).
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5525 226849 Ensembl ENSG00000066027 ENSMUSG00000026626 UniProt Q15172 Q6PD03 RefSeq (mRNA) NM_006243 NM_001199756 NM_144880 RefSeq (protein) NP_001186685 NP_006234 NP_659129 Location (UCSC) Chr 1: 212.29 – 212.36 Mb Chr 1: 191.08 – 191.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme ...