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RIPK1 protein is composed of 671 amino acids, and has a molecular weight of about 76 kDa. It contains a serine/threonine kinase domain (KD) in the 300 aa N-Terminus, a death domain (DD) in the 112 aa C-Terminus, and a central region between the KD and DD called intermediate domain (ID).
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The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
Each article at WikiPathways is dedicated to a particular pathway. Many types of molecular pathways are covered, including metabolic, [7] signaling, regulatory, etc. and the supported [8] species include human, mouse, zebrafish, fruit fly, C. elegans, yeast, rice and arabidopsis, [9] as well as bacteria and plant species.
Pathway links – click anywhere in the background on the pathway to go to the corresponding pathway article with an expanded view of the interactive pathway map; Variable-controlled cropped view – pathway maps can be cropped by referencing a gene or metabolite (see Usages #2 and #3 below).
United Nations Cartographic Section has many free maps in PDF format, at least some with the layers intact. However most UN maps are under UN copyright, so check before uploading. See here for their policy, this page about requesting permission. USGS Maps. Every USGS topographic map available for free download from the Internet Archive.
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