Search results
Results From The WOW.Com Content Network
The killing of microbes is a critical function of phagocytes that is performed either within the phagocyte (intracellular killing) or outside of the phagocyte (extracellular killing). [ 31 ] Oxygen-dependent intracellular
A cell that performs phagocytosis is called a phagocyte. The engulfing of a pathogen by a phagocyte. In a multicellular organism's immune system, phagocytosis is a major mechanism used to remove pathogens and cell debris. The ingested material is then digested in the phagosome.
Macrophages can express paracrine functions within organs that are specific to the function of that organ. In the testis , for example, macrophages have been shown to be able to interact with Leydig cells by secreting 25-hydroxycholesterol , an oxysterol that can be converted to testosterone by neighbouring Leydig cells. [ 15 ]
The mononuclear phagocyte system and the monocyte macrophage system refer to two different entities, often mistakenly understood as one. [citation needed] "Reticuloendothelial system" is an older term for the mononuclear phagocyte system, but it is used less commonly now, as it is understood that most endothelial cells are not macrophages. [2]
In cell biology, a phagosome is a vesicle formed around a particle engulfed by a phagocyte via phagocytosis. Professional phagocytes include macrophages, neutrophils, and dendritic cells (DCs). [1] A phagosome is formed by the fusion of the cell membrane around a microorganism, a senescent cell or an apoptotic cell.
Activation of phagocytes is the most common function attributed to Fc receptors. For example, macrophages begin to ingest and kill an IgG-coated pathogen by phagocytosis following engagement of their Fcγ receptors. [24] Another process involving Fc receptors is called antibody-dependent cell-mediated cytotoxicity (ADCC).
The phagocytic cells of the immune system include macrophages, neutrophils, and dendritic cells. Phagocytosis of the hosts' own cells is common as part of regular tissue development and maintenance. When host cells die, either by apoptosis or by cell injury due to an infection, phagocytic cells are responsible for their removal from the ...
Thus, their primary function is the homeostasis of the skin. ... They construct the mononuclear phagocyte system together with dendritic and Langerhans cells. [5]