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The male infertility crisis is an increase in male infertility since the mid-1970s. [91] The issue attracted media attention after a 2017 meta-analysis found that sperm counts in Western countries had declined by 52.4 percent between 1973 and 2011.
The 1990s saw significant development in research on male infertility, with reliable results indicating a decline. A 1992 Danish meta-analysis, commonly known as the Carlsen study after its principal author, showed that between 1938 and 1990 a population described as healthy had experienced a significant decrease in sperm count and semen volume.
YCT529 is a drug which acts as a potent and selective antagonist of the vitamin A receptor retinoic acid receptor alpha (RAR-α). In studies on mice it produced a 99% reduction in sperm production, and it has proceeded to early stage human clinical trials as a potential male contraceptive.
The trial involved 222 men, ages 18 to 50, who applied 5 milliliters of the gel (about a teaspoon) to each of their shoulder blades once per day. The second part of the two-part trial is still ...
By November 2019, the ICMR had successfully completed clinical trials of the world's first injectable male contraceptive, which was then sent to the Drug Controller General of India (DCGI) for regulatory approval. The trials were over, including extended, phase III clinical trials, for which 303 candidates were recruited with 97.3% success rate ...
Research shows men under 40 have lower testosterone than preceding generations. ... male infertility, and a higher risk of certain cancers. ... and an increased risk of clinical testosterone ...
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