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The association of serotonin with mood and cognition may explain some of the side-effects observed in patients treated with L-Dopa due to serotonin deficit. [9] [10] In most cases, motor symptoms predominate at early PD stages, while cognitive disturbances (such as mild cognitive impairment or dementia) emerge later. [11]
Symptoms are pain and tenderness at the radial side of the wrist, fullness or thickening over the thumb side of the wrist, painful radial abduction of the thumb, and difficulty gripping with the affected side of the hand. [2] Pain is made worse by movement of the thumb and wrist, and may radiate to the thumb or the forearm. [2]
Trapeziometacarpal osteoarthritis (TMC OA) is, also known as osteoarthritis at the base of the thumb, thumb carpometacarpal osteoarthritis, basilar (or basal) joint arthritis, or as rhizarthrosis. [ 3 ] [ 1 ] [ 2 ] This joint is formed by the trapezium bone of the wrist and the metacarpal bone of the thumb.
The main symptoms are pain in the hand, numbness, and tingling in the thumb, index finger, middle finger, and the thumb side of the ring finger. [1] Symptoms are typically most troublesome at night. [2] Many people sleep with their wrists bent, and the ensuing symptoms may lead to awakening. [7] Untreated, and over years to decades, CTS causes ...
The main symptom of benign fasciculation syndrome is focal or widespread involuntary muscle activity (fasciculation). [1] The benign twitches usually have a constant location. [2] Other common symptoms are generalized fatigue or weakness, paraesthesia or numbness, and muscle cramping or spasms. [1]
The disease is characterized by slowly progressive weakness and wasting of both proximal muscles (located on or close to the torso) and distal muscles (close to hands or feet), most apparent in the finger flexors and knee extensors. [3] IBM is often confused with an entirely different class of diseases, called hereditary inclusion body ...
Earlier signs of Lyme disease include the telltale bullseye-shaped rash and flu-like symptoms, such as fatigue, fever, headaches, muscle pain, and neck stiffness. Given Lyme’s murky mechanisms ...
The opponens pollicis causes the thumb to flex and rotate medially, leaving the thumb unable to oppose. Carpal tunnel syndrome can result in thenar muscle paralysis which can then lead to ape hand deformity if left untreated. [11] Ape hand deformity can also be seen in the hand of benediction deformity. [citation needed]