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Rheumatoid nodules can vary in size from 2 mm to 5 cm and are usually rather firm to the touch. Quite often they are associated with synovial pockets or bursae. About 5% of people with rheumatoid arthritis have such nodules within two years of disease onset, and the cumulative prevalence is about 20–30%. [4]
About 20% of people with rheumatoid arthritis develop rheumatoid nodules, which are linked to more severe erosive disease in those patients. [2] The nodules are more common in men, typically manifest in the fifth decade of life, and are primarily found on extensor surfaces like the backs of the fingers and elbows, though they can occur anywhere ...
Common sites for pannus formation include over the cornea, over a joint surface (as seen in rheumatoid arthritis), or on a prosthetic heart valve. [1] Pannus may grow in a tumor-like fashion, as in joints where it may erode articular cartilage and bone. In common usage, the term pannus is often used to refer to a panniculus (a hanging flap of ...
Nodules may form on tendons and muscles in response to injury, [7] and are frequently found on vocal cords, [8] They occur in conditions including endometriosis, [12] neurofibromatosis, [6] and in rheumatoid arthritis. [11] They may also feature in Kaposi's sarcoma [13] and gonorrhea. [14]
Rheumatoid arthritis [ edit ] Necrotizing granulomas can develop in patients with rheumatoid arthritis , typically manifesting as bumps in the soft tissues around the joints (so-called rheumatoid nodules) or in the lungs.
Caplan syndrome presents with cough and shortness of breath in conjunction with features of rheumatoid arthritis, such as painful joints and morning stiffness. Examination should reveal tender, swollen metacarpophalangeal joints and rheumatoid nodules; auscultation of the chest may reveal diffuse crackles that do not disappear on coughing or taking a deep breath.
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