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Breastfeeding and medications is the description of the medications that can be used by a breastfeeding mother, and the balance between maternal health and the safety of the breastfeeding infant. [1] [2] Medications, when administered to breastfeeding mothers, almost always are transferred to breast milk, albeit usually in small quantities. [3]
Diphenhydramine, while traditionally known as an antagonist, acts primarily as an inverse agonist of the histamine H 1 receptor. [68] It is a member of the ethanolamine class of antihistaminergic agents. [51] By reversing the effects of histamine on the capillaries, it can reduce the intensity of allergic symptoms.
Contraindications to breastfeeding are those conditions that could compromise the health of the infant if breast milk from their mother is consumed. Examples include galactosemia , untreated HIV , untreated active tuberculosis , Human T-lymphotropic virus 1 or II , uses illicit drugs , or mothers undergoing chemotherapy or radiation treatment .
Diphenhydramine is the primary constituent of dimenhydrinate and dictates the primary effect. The main differences relative to pure diphenhydramine are a lower potency due to being combined with 8-chlorotheophylline (by weight, dimenhydrinate is between 53% and 55.5% diphenhydramine) [10] and the fact that the stimulant properties of 8-chlorotheophylline help reduce the side ...
Use in pregnancy appears safe, but has not been well studied; use in breastfeeding is of unclear safety. [4] It is believed to work in part by anticholinergic and antihistamine mechanisms. [3] Meclizine was patented in 1951 and came into medical use in 1953. [5] It is available as a generic medication and often over the counter.
It is unclear if use during pregnancy or breastfeeding is safe. [8] It was first made by Union Chimique Belge in 1956 and was approved for sale by Pfizer in the United States later that year. [8] [10] In 2022, it was the 46th most commonly prescribed medication in the United States, with more than 13 million prescriptions. [11] [12]