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Cardiac index is a critical parameter in evaluating cardiac performance and the adequacy of tissue perfusion. In healthy adults, the normal range of cardiac index is generally between 2.6 to 4.2 L/min/m². Values below this range may indicate hypoperfusion and are often seen in conditions such as heart failure, hypovolemia, and cardiogenic shock.
Major factors influencing cardiac output – heart rate and stroke volume, both of which are variable. [1]In cardiac physiology, cardiac output (CO), also known as heart output and often denoted by the symbols , ˙, or ˙, [2] is the volumetric flow rate of the heart's pumping output: that is, the volume of blood being pumped by a single ventricle of the heart, per unit time (usually measured ...
Stroke volume is an important determinant of cardiac output, which is the product of stroke volume and heart rate, and is also used to calculate ejection fraction, which is stroke volume divided by end-diastolic volume. Because stroke volume decreases in certain conditions and disease states, stroke volume itself correlates with cardiac function.
Cardiac output as shown on an ECG. Cardiac output (CO) is a measurement of the amount of blood pumped by each ventricle (stroke volume, SV) in one minute. To calculate this, multiply stroke volume (SV), by heart rate (HR), in beats per minute. [1] It can be represented by the equation: CO = HR x SV [1]
Velocity Time Integral is a clinical Doppler ultrasound measurement of blood flow, equivalent to the area under the velocity time curve. The product of VTI (cm/stroke) and the cross sectional area of a valve (cm2) yields a stroke volume (cm3/stroke), which can be used to calculate cardiac output.
Therefore, using the assumed Fick determination, the approximated cardiac output for an average man (1.9 m3) is: Cardiac Output = (125 mL O 2 /minute × 1.9) / (200 mL O 2 /L − 150 mL O 2 /L) = 4.75 L/min. Cardiac output may also be estimated with the Fick principle using production of carbon dioxide as a marker substance. [3]
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Pulse pressure is calculated as the difference between the systolic blood pressure and the diastolic blood pressure. [3] [4]The systemic pulse pressure is approximately proportional to stroke volume, or the amount of blood ejected from the left ventricle during systole (pump action) and inversely proportional to the compliance (similar to elasticity) of the aorta.