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The NSG mouse (NOD scid gamma mouse) is a brand of immunodeficient laboratory mice, developed and marketed by Jackson Laboratory, which carries the strain NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ. NSG branded mice are among the most immunodeficient described to date. [1] NSG branded mice lack mature T cells, B cells, and natural killer (NK) cells. [2]
[16] [17] The demand for mice generated at The Jackson Lab increased in 1937 when the Surgeon General supported a grant from National Cancer Institute to the lab that made mice produced there a de facto industry standard due to federal standardization requirements because it was the only large-scale mouse provider before World War II. [17]
Mouse Genome Informatics (MGI) is a free, online database and bioinformatics resource hosted by The Jackson Laboratory, with funding by the National Human Genome Research Institute (NHGRI), the National Cancer Institute (NCI), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). [1]
The Jackson Laboratory in Bar Harbor, Maine is currently one of the world's largest suppliers of laboratory mice, at around 3 million mice a year. [5] The laboratory is also the world's source for more than 8,000 strains of genetically defined mice and is home of the Mouse Genome Informatics database. [6]
The first ob/ob mouse arose by chance in a colony at the Jackson Laboratory in 1949. [1] The mutation is recessive. Mutant mice are phenotypically indistinguishable from their unaffected littermates at birth, but gain weight rapidly throughout their lives, reaching a weight three times that of unaffected mice.
As the first model organisms were introduced into labs in the 20th century, these early efforts to identify standards to measure organisms against persisted. Beginning in the early 1900s Drosophila entered the research laboratories and opened up the doors for other model organisms like tobacco mosaic virus, E. coli, C57BL/6 (lab mice), etc ...
It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...
The Jackson Laboratory was (and still is) the world's mecca for mouse genetics. From 1933 to 1934, Snell was a teacher at Washington University in St. Louis . After brief stints as teachers, in 1935 Snell joined the staff of The Jackson Laboratory in Bar Harbor on Mount Desert Island on the coast of Maine and he remained there for the entire ...