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2. Hazard ratio - Wikipedia

   en.wikipedia.org/wiki/Hazard_ratio

   Kaplan-Meier curve illustrating overall survival based on volume of brain metastases.Elaimy et al. (2011) [6] In its simplest form, the hazard ratio can be interpreted as the chance of an event occurring in the treatment arm divided by the chance of the event occurring in the control arm, or vice versa, of a study.

3. Analysis of clinical trials - Wikipedia

   en.wikipedia.org/wiki/Analysis_of_clinical_trials

   Clinical trials are medical research studies conducted on human subjects. [1] The human subjects are assigned to one or more interventions, and the investigators evaluate the effects of those interventions. [1] [2] The progress and results of clinical trials are analyzed statistically. [3] [4]

4. Rule of three (statistics) - Wikipedia

   en.wikipedia.org/wiki/Rule_of_three_(statistics)

   The rule is useful in the interpretation of clinical trials generally, particularly in phase II and phase III where often there are limitations in duration or statistical power. The rule of three applies well beyond medical research, to any trial done n times. If 300 parachutes are randomly tested and all open successfully, then it is concluded ...

5. Medical statistics - Wikipedia

   en.wikipedia.org/wiki/Medical_statistics

   Medical statistics (also health statistics) deals with applications of statistics to medicine and the health sciences, including epidemiology, public health, forensic medicine, and clinical research. [1] Medical statistics has been a recognized branch of statistics in the United Kingdom for more than 40 years, but the term has not come into ...

6. Intention-to-treat analysis - Wikipedia

   en.wikipedia.org/wiki/Intention-to-treat_analysis

   Randomized clinical trials analyzed by the intention-to-treat (ITT) approach provide unbiased comparisons among the treatment groups. Intention to treat analyses are done to avoid the effects of crossover and dropout, which may break the random assignment to the treatment groups in a study.

7. Adaptive design (medicine) - Wikipedia

   en.wikipedia.org/wiki/Adaptive_design_(medicine)

   Schematic block diagram of an adaptive design for a clinical trial [1] In an adaptive design of a clinical trial, the parameters and conduct of the trial for a candidate drug or vaccine may be changed based on an interim analysis. [2] [1] [3] Adaptive design typically involves advanced statistics to interpret a clinical trial endpoint. [1]