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By reducing LDL cholesterol, statins can also help lower a person’s risk for cardiovascular diseases such as heart failure, coronary heart disease, heart attack, and stroke.
It can increase the risk of serious cardiovascular events, such heart attack and stroke. Statins are a medication type that can help people at risk for atherosclerotic cardiovascular disease ...
High cholesterol: In particular, elevated LDL (low-density lipoprotein) cholesterol can build up your arteries, increasing your stroke risk. ... Stroke recovery can be a long journey, but it is ...
On average, statins can lower LDL cholesterol by 1.8 mmol/L (70 mg/dL), which translates into an estimated 60% decrease in the number of cardiac events (heart attack, sudden cardiac death) and a 17% reduced risk of stroke after long-term treatment. [36] A greater benefit is observed with high-intensity statin therapy. [37]
JUPITER was a randomized double-blind placebo-controlled study investigating the use of rosuvastatin in the primary prevention of cardiovascular disease.The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP).
[26] [27] In particular, ezetimibe and statin dual therapy have shown a 15% greater LDL-C decrease compared with same-dose statins alone, favouring recovery from acute coronary syndrome. [23] Whilst ezetimibe intolerance is uncommon, some reports have been made regarding gastrointestinal and musculoskeletal effects. [28]