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Tailoring the dosage of gonadotrophin administration to AMH level has been shown to reduce the incidence of excessive response and cancelled cycles. [5] Elevated basal follicle stimulating hormone (FSH) levels imply a need of more ampoules of gonadotropins for stimulation, and have a higher cancellation rate because of poor response. [11]
A tiny fraction of patients may still have measurable sperm levels. [1] About 90% of those with Sertoli cell-only syndrome have elevated FSH levels, usually two to three times the normal amount. [1] Testicular biopsy is the only way to confirm non-obstructive azoospermia and Sertoli cell-only syndrome. [1]
The most common reason for high serum FSH concentration is in a female who is undergoing or has recently undergone menopause. High levels of FSH indicate that the normal restricting feedback from the gonad is absent, leading to an unrestricted pituitary FSH production. FSH may contribute to postmenopausal osteoporosis and cardiovascular disease ...
FSH and recombinant FSH analogues are mainly used for controlled ovarian hyperstimulation as well as ovulation induction. [12] There has been some controversy over the efficacy between extracted and recombinant FSH for ovulation induction; however, a meta-analysis of 14 trials among 1726 women found that there were no differences in clinical ...
For both males and females, the initial aim for treatment is the development of the secondary sexual characteristics normally seen at puberty. [3] [39] [34] [35] [40] Once this has been achieved, continued hormone replacement therapy is required for both males and females to maintain sexual function, bone health, libido and general wellbeing. [4]
A gonadotropin-releasing hormone agonist (GnRH agonist) is a type of medication which affects gonadotropins and sex hormones. [1] They are used for a variety of indications including in fertility medicine and to lower sex hormone levels in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer, certain gynecological disorders like heavy periods and endometriosis ...
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