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Guaifenesin/codeine is a fixed-dose combination cold medicine used for the treatment of cough. [1] It contains guaifenesin, an expectorant; and codeine, as the phosphate, an opioid antitussive. [1] It is taken by mouth. [1] It was approved for medical use in the United States in 2006. [1]
Guaifenesin might act as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi via stimulation of the gastric mucosa. . This stimulation leads to an increased parasympathetic activity in the respiratory tract via the so-called gastro-pulmonary reflex, although some in vitro studies suggested that it might also act directly on the ...
As a cough suppressant, the polistirex version lasts up to 12 hours. This duration also holds true when used recreationally. In 1981, a paper by Gosselin estimated that the lethal dose is between 50 and 500 mg/kg. Doses as high as 15–20 mg/kg are taken by some recreational users.
Lean or purple drank (known by numerous local and street names) is a polysubstance drink used as a recreational drug.It is prepared by mixing prescription-grade cough or cold syrup containing an opioid drug and an anti-histamine drug with a soft drink and sometimes hard candy.
Codeine linctus of 15 mg per 5 ml is also available at some pharmacies, although a purchaser would have to request it specifically from the pharmacist. [ citation needed ] Under the Misuse of Drugs Act 1971 codeine is a Class B controlled substance or a Class A drug when prepared for injection.
It is sold over the counter in France, Morocco, Egypt, Algeria, South Korea and the UAE [citation needed]. The oxomemazine ingredient (antihistamine) is not approved by the U.S. Food and Drug Administration (FDA), either for over the counter or prescription use. It is sold in France as cough syrup.
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