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Midazolam is known to cause respiratory depression. In healthy humans, 0.15 mg/kg of midazolam may cause respiratory depression, which is postulated to be a central nervous system (CNS) effect. [48] When midazolam is administered in combination with fentanyl, the incidence of hypoxemia or apnea becomes more likely. [49]
Additionally, IV sedation is frequently administered as a concoction of several agents including those previously mentioned for induction and maintenance of anesthesia, as well as a benzodiazepine (usually midazolam, but temazepam or flunitrazepam are also used via the oral route [4]) and a narcotic/systemic analgesic such as demerol or fentanyl.
Although meperidine (Demerol) may be used as an alternative to fentanyl, the concern of seizures has relegated this agent to second choice for sedation behind the combination of fentanyl and midazolam. The average person will receive a combination of these two drugs, usually between 25 and 100 μg IV fentanyl and 1–4 mg IV midazolam. Sedation ...
What is fentanyl? A look at the drug at the center of a recent major narcotics bust. According to the Centers for Disease Control and Prevention, 107,735 Americans died between August 2021 and ...
Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic. It is 30 to 50 times more potent than heroin and 50 to 100 times more potent ...
Usual doses for midazolam are 1 mg to 2 mg where the older people receive smaller doses and obese people receive higher doses. Midazolam is metabolized in the liver and is excreted through the kidneys. [9] When midazolam is used alone, it has few side effects, but can cause respiratory depression if being used together with fentanyl. [8]
The death toll from fentanyl is falling as communities flood the streets with naloxone, an overdose-reversal drug. But deadly opioids remain rife. A fentanyl antidote is saving lives.
Fentanyl is a synthetic opioid, 75-125 times stronger than morphine, [3] that acts by activating opioid receptors in the nervous system. Its effects begin in 2–3 minutes, and last 30–60 minutes. Fentanyl provides analgesia and sedative properties; it does not have any amnestic effects.