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  2. Elevated transaminases - Wikipedia

    en.wikipedia.org/wiki/Elevated_transaminases

    The magnitude of AST and ALT elevations vary depending on the cause of the increase, such as intensity of recent muscular exertion or type of hepatocellular injury. The following refer to the " upper reference limit " (URL), also known as the "upper limit of normal" (ULN), which depend on the source and are typically 40-50 U/L (0.67-0.83 μkal ...

  3. Liver function tests - Wikipedia

    en.wikipedia.org/wiki/Liver_function_tests

    ALP activity is significantly increased in the third trimester of pregnancy. [11] This is due to increased synthesis from the placenta as well as increased synthesis in the liver induced by large amounts of estrogens. [11] [12] [13] Levels in the third trimester can be as much as 2-fold greater than in non-pregnant women. [11]

  4. AST/ALT ratio - Wikipedia

    en.wikipedia.org/wiki/AST/ALT_ratio

    The proportion of AST to ALT in hepatocytes is about 2.5:1, but because AST is removed from serum by the liver sinusoidal cells twice as quickly (serum half-life t 1/2 = 18 hr) compared to ALT (t 1/2 = 36 hr), so the resulting serum levels of AST and ALT are about equal in healthy individuals, resulting in a normal AST/ALT ratio around 1.

  5. Hepatitis - Wikipedia

    en.wikipedia.org/wiki/Hepatitis

    [33] [50] As with other autoimmune diseases, autoimmune hepatitis usually affects young females (though it can affect patients of either sex of any age), and patients can exhibit classic signs and symptoms of autoimmunity such as fatigue, anemia, anorexia, amenorrhea, acne, arthritis, pleurisy, thyroiditis, ulcerative colitis, nephritis, and ...

  6. Alanine transaminase - Wikipedia

    en.wikipedia.org/wiki/Alanine_transaminase

    Alanine transaminase (ALT), also known as alanine aminotransferase (ALT or ALAT), formerly serum glutamate-pyruvate transaminase (GPT) or serum glutamic-pyruvic transaminase (SGPT), is a transaminase enzyme (EC 2.6.1.2) that was first characterized in the mid-1950s by Arthur Karmen and colleagues. [1]

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  8. Acute liver failure - Wikipedia

    en.wikipedia.org/wiki/Acute_liver_failure

    Common causes for acute liver failure are paracetamol (acetaminophen) overdose, idiosyncratic reaction to medication (e.g. tetracycline, troglitazone), excessive alcohol consumption (severe alcoholic hepatitis), viral hepatitis (hepatitis A or B—it is extremely uncommon in hepatitis C), acute fatty liver of pregnancy, and idiopathic (without ...

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