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3351 15551 Ensembl ENSG00000135312 ENSMUSG00000049511 UniProt P28222 P28334 RefSeq (mRNA) NM_000863 NM_010482 RefSeq (protein) NP_000854 NP_034612 Location (UCSC) Chr 6: 77.46 – 77.46 Mb Chr 9: 81.51 – 81.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 5-hydroxytryptamine receptor 1B also known as the 5-HT 1B receptor is a protein that in humans is encoded by the HTR1B gene ...
The 5-HT 1 subfamily consists of five G protein-coupled receptors (GPCRs) that share 40% to 63% overall sequence homology, including 5-HT 1A, 5-HT 1B, 5-HT 1D, 5-HT 1E, and 5-HT 1F. [2] Receptors of the 5-HT 1 type, specifically, the 5-HT 1A and 5-HT 1D receptor subtypes, are present on the cell bodies. Receptors of the 5-HT1 type, specifically ...
5-HT receptors are all G-protein coupled receptors (GPCR) except for 5-HT 3 which is a ligand gated ion channel. The receptors that have been found to be involved in migraine are 5-HT 1B, 5-HT 1D and 5-HT 1F receptors. 5-HT 1B are found in meningeal arteries, agonism of 5-HT 1B causes vasoconstriction in cranial nerves
The 5-HT 1B receptor as an example of a metabotropic serotonin receptor. Its crystallographic structure in ribbon representation. 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
GR-55562 is a selective serotonin 5-HT 1B and 5-HT 1D receptor antagonist. [1] It is one of several selective serotonin 5-HT 1B receptor antagonists used in scientific research. [2] [3] The drug is a silent antagonist of the serotonin 5-HT 1B receptor, unlike the related agent GR-127935.
CP-93129 is a drug which acts as a potent and selective serotonin 5-HT 1B receptor agonist, with approximately 150x and 200x selectivity over the closely related 5-HT 1D and 5-HT 1A receptors. [1] It is used in the study of 5-HT 1B receptors in the brain, particularly their role in modulating the release of other neurotransmitters. [2] [3] [4] [5]
CP-94253 is a drug which acts as a potent and selective serotonin 5-HT 1B receptor agonist, with approximately 25× and 40× selectivity over the closely related 5-HT 1D and 5-HT 1A receptors. [1] It has a range of behavioral effects, based on animal testing.
CGS-12066A is a drug which acts as a potent and selective agonist for the 5-HT 1B receptor with lower affinity for the three 5-HT 2 receptor subtypes. [1] [2] It is used for studying the role of the 5-HT 1B receptor in various processes including perception of pain and the sleep-wake cycle.