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The routine use of VLCDs is not recommended due to safety concerns, but this approach can be used under medical supervision if there is a clinical rationale for rapid weight loss in obese individuals, as part of a "multi-component weight management strategy" with continuous support and for a maximum of 12 weeks, according to the NICE 2014 guidelines. [12]
Bupropion, formerly called amfebutamone, [16] and sold under the brand name Wellbutrin among others, is an atypical antidepressant that is indicated in the treatment of major depressive disorder, seasonal affective disorder and to support smoking cessation.
The Kurus and Krivis (Panchala) are said to form the Vaikarana of Rigveda and the Vaikarana is often identified with Kashmir. Therefore, Dr Zimmer likes to identify the Vaikarana Kurus with the Uttarakurus and places them in India's Kashmir. [9] German-American historian, Michael Witzel locates Uttarakuru in the south-eastern parts of Central Asia.